Early diagnosis, prognosis of cancers by genomics data and bioinformatics analysis. We are developing computational methods (e.g. machine learning methods) to integrate big data related to precision medicine.
Post-transcriptional regulation plays essential role in basic biological processes. Most post-transcriptional regulation events are regulated by RNA's structure and its binding proteins. RNA-binding proteins (RBPs) bind to double or single stranded RNA and participate in forming ribonucleoprotein complexes.
RNA often forms complicated base-pairing interactions due to its increased ability to form hydrogen bonds stemming from the extra hydroxyl group in the ribose sugar.