Oligo (siRNA) targeting mRNA and lncRNA (long noncoding RNA)
Ligand targeting structured noncoding RNA
Design RNA vaccine by optimizing UTR sequence, free energy change and codon usage
Design RNA enzyme by optimizing sequence and structure
Cell-free RNA (cfRNA) discovery for disease diagnosis and prognosis, for instance, early cancer screen
Lead Science
Lead Bioinformatics
Lab Management
我们的科研成果:
基于机器学习的生物信息方法RNAfinder(专利号:201610806928.8)(Science 2010; Genome Res. 2011; Nucleic Acids Res. 2015;2017a;2018);
痕量RNA捕获和测序技术i-SMART (专利号:201810607652X)(Briefings in Bioinformatics 2018; Cell Research 2020);
痕量cfRNA捕获和测序技术DETECTOR (专利申请号:202210579444.X)(eLife 2022; Cell Rep. MED 2023)。
我们的科研成果:
RNA secondary structure prediction algorithm and server (Nucleic Acids Res. 2006,RNA 2009, Nucleic Acids Res. 2015,2016)。
我们的科研成果:
RNA-protein 结合及调控数据库 POSTAR(软件著作权号:2016R11S367236)(Genome Biology 2017; Nucleic Acids Res. 2017b; 2019; 2022)。
我们的科研成果:
siRNA design algorithm and server, OligoWalk (Nucleic Acids Res. 2008a,b,c);
靶标HIV、HCV等病毒的shRNA设计(PNAS 2012);
靶标病毒的小分子药物组合的筛选(Natture Biotech. 2012) ;
针对肝癌的一个新cfRNA标志物(专利号:201811009464.3)(Clinical Chem. 2019);
肝细胞癌早期筛查和复发监测的3ncRNA (专利号:202010927225.7)(Theranositcs 2020);
鉴定胞外RNA生物标志物的试剂盒及算法 exSEEK(专利申请号:202010618721.4)(Nuc. Acids Res. 2024);
体液多组学 AI整合方法 PathFormer (软件注册权号:2023SR0985659)(Bioinformatics 2024);
siRNA AI 设计软件 OligoFormer (软件注册权号:2024SR0808920)(preprint 2024)。
已发表科研论文: