Cancer Immunotherapy

1. Cancer Immunotherapy

2024 Cell - Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response characteristics in patients with cancer
2024 Cancer Cell - Integrated multi-omics profiling to dissect thespatiotemporal evolution of metastatichepatocellular carcinoma
[review] 2023 Cell - Delivering the next generation of cancer immunotherapies with RNA
2023 Cancer Cell - ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome
2023 Cancer Cell - The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients
✅ (neoadjuvant biomarker) 2022 Mol. Cancer - A liquid biopsy signature of circulating exosome-derived mRNAs, miRNAs and lncRNAs predict therapeutic efficacy to neoadjuvant chemotherapy in patients with advanced gastric cancer
✅ (neoadjuvant) 2022 Cell - Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy
(neoadjuvant) 2022 Nature Med - Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer
2021 Cancer Cell - Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer
(non-neo adjuvant) 2021 Nature - ctDNA guiding adjuvant immunotherapy in urothelial carcinoma
2020 Science Advance - Multi-omics characterization of molecular features of gastric cancer correlated with response to neoadjuvant chemotherapy

2. Cancer microenvironment

2019 - Nat Genetics - Landscape of B cell immunity and related immune evasion in human cancers
2018 - Nat Biotech - Evaluation of immune repertoire inference methods from RNA-seq data
2016 - Nature Genetics - Landscape of tumor-infiltrating T cell repertoire of human cancers
[srpRNA] 2021 Cell - The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
[srpRNA] 2017 Cell - Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

3. Neoantigen

[review] 2021 Nature - Advances in the development of personalized neoantigen-based therapeutic cancer vaccines
[review] 2017 Cell - Applications of Immunogenomics to Cancer
2020 NCOMM - Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate