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ncRNA in Cancer

: recommended readings

0. Basics

  • ✅ [Review] 2021 Nature Review | Cancer - Long noncoding RNAs in cancer metastasis
  • 2021 Nature Biotechnology - The RNA Atlas expands the catalog of human non-coding RNAs
  • 2020 Nature - PCAWG - Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
  • 2020 Nature - PCAWG - Genomic basis for RNA alterations in cancer
  • ✅ [Review] 2019 Cell The Role of Non-coding RNAs in Oncology
  • [lncRNA Profiling] 2015 Nature Genetics - MiTranscriptome - The Landscape of Long Noncoding RNAs in the Human Transcriptome

I. Novel ncRNAs

  • 2024 Nature Genetics - Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
  • [Perspective] 2022 Nature Cell Biology - Exploring the expanding universe of small RNAs
  • 2021 Nature Cell Biology - PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

II. TE-RNA/Repeats

  • 2024 Nature reviews cancer - Towards targeting transposable elements for cancer therapy
  • 2024 Genome Biology - Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes
  • [review] 2017 Nature Reviews Cancer - Transposable elements in cancer
  • 2022 Nature Genetics - LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion

III. tsRNA/rsRNA and MT-RNA

  • [Function] 2022 Cell Metab. - Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth
  • [Marker] 2022 Frontier Medicine - Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
  • [Function] 2021 Mol. Cancer - A novel class of tsRNA signatures as biomarkers for diagnosis and prognosis of pancreatic cancer
  • [Profiling] 2020 NAR - Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
  • [Marker] 2019 Mol. Cancer - Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis
  • [Function] 2015 Cell - Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement

IV. circRNA

  • [Review] 2021 Mol Cancer Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies
  • [Function] 2020 Signal Transduction and Targeted Therapy CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX
  • [Review] 2019 EMBJ Past, present, and future of circRNAs
  • 2013 Nature Circular RNAs are a large class of animal RNAs with regulatory potency

V. Other noncoding RNAs

  • [srpRNA] 2021 Cell - The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
  • [srpRNA] 2017 Cell - Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer