ncRNA in Cancer
✅ : recommended readings
0. Basics
- ✅ [Review] 2021 Nature Review | Cancer - Long noncoding RNAs in cancer metastasis
- 2021 Nature Biotechnology - The RNA Atlas expands the catalog of human non-coding RNAs
- 2020 Nature - PCAWG - Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
- 2020 Nature - PCAWG - Genomic basis for RNA alterations in cancer
- ✅ [Review] 2019 Cell The Role of Non-coding RNAs in Oncology
- [lncRNA Profiling] 2015 Nature Genetics - MiTranscriptome - The Landscape of Long Noncoding RNAs in the Human Transcriptome
I. Novel ncRNAs
- ✅ 2024 Nature Genetics - Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
- [Perspective] 2022 Nature Cell Biology - Exploring the expanding universe of small RNAs
- ✅ 2021 Nature Cell Biology - PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications
II. TE-RNA/Repeats
- 2024 Nature reviews cancer - Towards targeting transposable elements for cancer therapy
- ✅ 2024 Genome Biology - Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes
- [review] 2017 Nature Reviews Cancer - Transposable elements in cancer
- 2022 Nature Genetics - LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion
III. tsRNA/rsRNA and MT-RNA
- [Function] 2022 Cell Metab. - Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth
- [Marker] 2022 Frontier Medicine - Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
- [Function] 2021 Mol. Cancer - A novel class of tsRNA signatures as biomarkers for diagnosis and prognosis of pancreatic cancer
- [Profiling] 2020 NAR - Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
- [Marker] 2019 Mol. Cancer - Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis
- [Function] 2015 Cell - Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement
IV. circRNA
- [Review] 2021 Mol Cancer Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies
- [Function] 2020 Signal Transduction and Targeted Therapy CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX
- [Review] 2019 EMBJ Past, present, and future of circRNAs
- 2013 Nature Circular RNAs are a large class of animal RNAs with regulatory potency
V. Other noncoding RNAs
- [srpRNA] 2021 Cell - The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
- [srpRNA] 2017 Cell - Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer