RNA in Immune System

✅ : recommended readings

1. dsRNA and immunity

Background/Introduction

[IRAlus Review] 2024 Experimental & Molecular Medicine - Inverted Alu repeats: friends or foes in the human transcriptome
2024 Molecular Cell - The competitive landscape of the dsRNA world
2024 Nature - dsRNA formation leads to preferential nuclear export and gene expression
✅ 2024 Nature Reviews Immunology - Novel insights into double-stranded RNA-mediated immunopathology
✅ 2022 Nature Review - Mol Cell Biol. - Cellular origins of dsRNA, their recognition and consequences
2021 Cancer Discovery - Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin
2022 Nature Reviews Immunology - The roles of extracellular vesicles in the immune system
2022 Immunity - Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity
2021 Genome Biology - Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways
[review] 2019 noncoding RNA - Endogenous Double-Stranded RNA
2018 - JCO - Immune checkpoint molecule expression measured using circulating cell-free RNA isolated from the blood of metastatic prostate cancer patients.
✅ 2016 Cell Host & Microbe - The Evolution of Antiviral Defense Systems

✅ 2024 Immunity - Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells
2023 Science Immunology - Epigenetically controlled tumor antigens derived from splice junctions between exons and transposable elements
[review] 2022 Journal of Autoimmunity - Evolving understandings for the roles of non-coding RNAs in autoimmunity and autoimmune disease
[review] 2022 Journal of Autoimmunity - Non-coding RNAs in immunoregulation and autoimmunity: Technological advances and critical limitations
[srpRNA] 2021 Cell - The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function
[srpRNA] 2017 Cell - Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer
2012 Nature Reviews Rheumatology - MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis

✅ 2022 Nature - RNA editing underlies genetic risk of common inflammatory diseases
2022 Cancer Res. - Single-cell analysis in lung adenocarcinoma implicates RNA editing in cancer innate immunity and patient prognosis
2020 Genome Biology - Human A-to-I RNA editing SNP loci are enriched in GWAS signals for autoimmune diseases and under balancing selection
2018 Cell - Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

✅ [review] 2023 Trends in Immunology - ‘(m 6 )A’ stands for ‘autoimmunity’: reading, writing, and erasing RNA modiﬁcations during inﬂammation
✅ 2020 Immunity - m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development