[Protein markers] 2016 Lancet Neurol - CSF and blood biomarkers for the diagnosis of Alzheimer's disease- a systematic review and meta-analysis
[DNA markers] 2014 Nat Genetics - Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk
[lncRNA markers] 2005 Cancer Res. - Identification of GATA3 as a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis
[Practical Review] 2015 Korean J Radiol Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers
Part I. General Guidance and Tips
Part II. Statistical Methods of Meta-Analysis
III. Large-cohort Validation/Screen
cfRNA Panels
2022 Mol Cancer - A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study
✨ miRNA panel: 2022 Mol Cancer - A microRNA-based liquid biopsy signature for the early detection of esophageal squamous cell carcinoma: a retrospective, prospective and multicenter study
✨ circRNA panel: 2022 Mol Cancer - Diagnostic efcacy of circular RNAs as noninvasive liquid biopsy biomarkers for early detection of gastric cancer
✨ mRNA panel: 2021 Mol Cancer - Circulating exosomal mRNA profiling identifies novel signatures for the detection of prostate cancer
lncRNAs+miRNAs: 2021 Theranostics -Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer
miRNAs:2020 Gut - Development and validation of a serum microRNA biomarker panel for detecting gastric cancer in a high-risk population
miRNAs:2020 PNAS - Development of a serum miRNA panel for detection of early stage non-small cell lung cancer
✨ small exosomal RNA:2019 Molecular Cancer - Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosis
✨ miRNA7: 2011 JCO - Jia Fan - Plasma MicroRNA Panel to Diagnose Hepatitis B Virus–Related Hepatocellular Carcinoma
Other Detection/Diagnosis Panels
✅ (neoadjuvant biomarker) 2022 Mol. Cancer- A liquid biopsy signature of circulating exosome-derived mRNAs, miRNAs and lncRNAs predict therapeutic efficacy to neoadjuvant chemotherapy in patients with advanced gastric cancer
✅ (SLE biomarker) 2022 Lancet Rheumatol - Identification of biomarkers to stratify response to B-cell-targeted therapies in systemic lupus erythematosus: an exploratory analysis of a randomised controlled trial
ctDNA+Protein (CancerSEEK): 2018 - Science - Detection and localization of surgically resectable cancers with a multi-analyte blood test
2019 - iScience - Early Cancer Detection from Multianalyte Blood Test Results
2021 - Bioinformatics - CancerEMC frontline non-invasive cancer screening from circulating protein biomarkers and mutations in cell-free DNA
ctDNA+Protein+Clinical Info: 2019 - PNAS - Detection of early-stage hepatocellular carcinoma in asymptomatic HBsAg-seropositive individuals by liquid biopsy
Other Prognosis Panels
Progosis ctDNA: 2019 JCO - Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma
Prognosis ctDNA: 2019 JAMA Oncology - Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer
Prognosis ctDNA: 2019 Translational Med. - Personalized circulating tumor DNA analysis to detect residual disease after neoadjuvant therapy in breast cancer
Prognosis ctDNA：2019 JAMA Oncology - Circulating Tumor DNA Analyses as Markers of Recurrence Risk and Benefit of Adjuvant Therapy for Stage III Colon Cancer
Liquid vs. tissue biopsy： 2019 Nature Medicine - Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers