Skip to content

AI Virtual Cell (AIVC) for Omics

MultiOmics --> Multimodal AIVC

  • MultiOmics Methods
    • 2024 Nature Methods - Benchmarking algorithms for single-cell multi-omics prediction and integration
    • 2023 Nature Methods - SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks
  • Foundation Models
    • 2025 Nature Methods - EpiAgent: foundation model for single-cell epigenomics
    • 2024 Nature Methods - Large-scale foundation model on single-cell transcriptomics
  • AIVC studies
    • 👍 2026 Nature Methods - Decoding sequence determinants of gene expression in diverse cellular and disease states
    • 2026 bioRxiv - Unified modeling of cellular responses to diverse perturbation types
    • 2026 Nature Comp. Sci. - Partially shared multi-modal embedding learns holistic representation of cell state
    • Read more about Digital Twin for Medicine

MultiOmis Anaysis

MultiOmics Analysis Examples:

Chinese Immune Multi-Omics Atlas

Science 2026

More:

[RNA-Protein] RBP & Post-transcriptional Regulation

  • 2025 Nature biotechnology - A resource of RNA-binding protein motifs across eukaryotes reveals evolutionary dynamics and gene-regulatory function
  • 2015 Nature Biotech. - DeepBind: Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning
  • POSTAR3 - NAR 2022 [Lu Lab Paper]
  • RBPgroup - Genome Biology 2017 [Lu Lab Paper]

[RNA-DNA/RNA]

  • MUSIC 2024 Nature - Single-cell multiplex chromatin and RNA interactions in ageing human brain
  • RIC-seq 2020 Nature - RIC-seq for global in situ profiling of RNA–RNA spatial interactions