AI for noncoding RNA (ncRNA)
I. AI models for RNA
- 👍 2026 Nature Methods - Orthrus: toward evolutionary and functional RNA foundation models
- 2026 Cell - Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles
- 👍 [Roadmap] 2025 Nature Reviews - Decoding the interactions and functions of non-coding RNA with artificial intelligence
- 2026 Nature - Advancing regulatory variant effect prediction with AlphaGenome
- 2024 Nature Machine Intelligence - An interpretable RNA foundation model for exploring functional RNA motifs in plants
- New models
- RiNALMo, HydraRNA, RNAErnie, Ernie-RNA, structRFM, ...
II. mbRNAfinder
- 👍 2021 Genome Biology - Comparative genomics identifies thousands of candidate structured RNAs in human microbiomes
- 2024 Nature Biotechnology - RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators
- Database:
III. Ribozyme/Aptamer Design
- 👍 2026 Nature Biotechnology - Single-round evolution of RNA aptamers with GRAPE-LM
- 2026 Nature computational science - De novo design of functional nucleic acids of aptamers
- 2024 Nature Methods - [RfamGen]Deep generative design of RNA family sequences
- 2024 Nature machine intelligence - A 5′ UTR language model for decoding untranslated regions of mRNA and function predictions